Lipid‐based gene delivery to macrophage mitochondria for atherosclerosis therapy
نویسندگان
چکیده
منابع مشابه
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autophagy-lysosome system contributes to this as evidenced by a derangement in key autophagy markers in...
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ژورنال
عنوان ژورنال: Pharmacology Research & Perspectives
سال: 2020
ISSN: 2052-1707,2052-1707
DOI: 10.1002/prp2.584